Figure 3.

Spatial regulation of transmitter release by the I-II loop interaction with SNAREs. (a) The I-II loop interacts with t-SNAREs, resulting in inhibition of Ca2.2 channels opening. Once AP opens the channels, an increase in Ca²⁺ mediates interaction with SNAREs complex and induces transmitter release. Adapted from [4]. (b) Triple APs induces a large synchronous transmitter release from the first AP. In contrast, asynchronous transmitter release was observed in the presence of 130 μM synprint peptide (see Figure 1b). Adapted from [99].