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. 2019 May 24;14:3743–3752. doi: 10.2147/IJN.S193258

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© 2019 Ha et al.

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Scheme 1 — Complexation of microbubble and NIR-Alb NP. (A) and NIR-Alb NP complex delivery to brain tumor by ultrasound; (B) NIR-Alb NP can be bound on NHS-activated MB by amide bonding coupling. The as-prepared complex is administrated via tail-vein intravenous injection. When ultrasound is applied in brain tumor site, the complex is oscillated and destroyed, opening the BBB. Finally, the nanoparticle can be delivered to tumor site in the brain.

Abbreviations: BBB, blood–brain barrier; MB, microbubble; NHS, hydroxysuccinimide; NIR-Alb NP, near-infrared dye-incorporated albumin nanoparticle.

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