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Increasing lipidation of the astrocytic pool of apoE. Astrocytes are the primary producer of apoE in the brain. Common mechanisms of apoE and abca1 expression are driven by nuclear hormone receptor (such as LXR and RXR) activation. Abca1 is critical for lipidation of apoE and increasing expression of abca1 leads to increased lipidation of all apoE isoforms (indicated by green arrows). We hypothesize that increasing apoE lipidation will be beneficial for several AD-relevant endpoints.
