Figure 1.

7DMA treatment reduces ZIKV replication in male reproductive organs. Male AG129 mice (6-12 weeks of age) were inoculated intraperitoneally with 10⁴ PFU of ZIKV (SL1602, Suriname isolate). (a) Schematic representation of the study design. Starting from the day of infection (i.e., day 0), mice were treated once daily with 50 mg/kg/dose of 7DMA or vehicle via oral gavage for 7 consecutive days. The inhibitory effect of 7DMA on ZIKV replication in plasma (b), the testis (c,e), and the epididymis (d) is compared between vehicle-treated mice (black, n = 8, 17, and 6) and mice treated with 7DMA (white, n = 8, 13, and 8) at day 3, 7, and 10 pi, respectively. Data are presented as medians and statistical analysis was performed using the Mann-Whitney U test, * = p ≤ 0.008, ** = p ≤ 0.0006 (Graphpad software). GE; genome equivalents. The dotted line represents the limit of detection. Data from day 7 pi are from two independently performed experiments.