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. 2019 May 22;10:560. doi: 10.3389/fphys.2019.00560

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Copyright © 2019 Yawno, Sutherland, Pham, Castillo-Melendez, Jenkin and Miller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative micrographs of cresyl violet and acid fuchsin staining in a 115 d GA fetus and 1-day-old lamb of control (A,C,E,G) and FGR (B,D,F,H) brain. (A–D) show measurements of EGL and ML on each image. Within FGR brains, note the presence of vacuolization in parenchymal WM tissue (F) and Purkinje neurons with abnormally shaped, darkly stained nuclei (H). EGL, external granular layer; ML, molecular layer; PCL, Purkinje cell layer; WM, white matter. Scale bar for (A–D) in (D) = 100 μm and (E–H) in (H) = 50 μm.