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. 2019 May 22;10:560. doi: 10.3389/fphys.2019.00560

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Copyright © 2019 Yawno, Sutherland, Pham, Castillo-Melendez, Jenkin and Miller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The number of Iba-1-positive cells (A–C) and 8-hydroxy-2-deoxyguanosine (8-OHdG)-positive cells (D–F) in the molecular layer (ML), internal granular layer (IGL), and white matter (WM) in the fetal brain at 115 d GA, 124 d GA, and 1-day-old lamb of control and FGR animals. Each bar represents the mean ± SEM; *p ≤ 0.05 versus control. Representative micrographs showing Iba-1- (G,H) and 8-OHdG- (I,J) positive immunoreactivity in the WM in 124 d GA (G,H) and 1-day-old lambs (I,J). Images from control (G,I) and FGR (H,J) animals are shown. FGR, fetal growth restriction. Scale bar = 25 μm.