Table 1.
Fetal and neonatal outcomes.
| 115 d GA | 124 d GA | 1-day-old lamb | ||||
|---|---|---|---|---|---|---|
| Control | FGR | Control | FGR | Control | FGR | |
| Number of ewes | 6 | 5 | 8 | 7 | ||
| Number of fetuses | 6 | 6 | 5 | 5 | 8 | 7 |
| GA at surgery | 107 ± 1.0 | 107 ± 1.0 | 104 ± 0.6 | 104 ± 0.8 | 105 ± 1.2 | 105 ± 0.9 |
| Male:female | 4:2 | 4:2 | 2:3 | 2:3 | 4:4 | 3:4 |
| Body weight (kg) | 1.9 ± 0.2 | 1.6 ± 0.1 | 3.5 ± 0.1 | 2.5 ± 0.2 * | 4.8 ± 0.5 | 3.5 ± 0.5 * |
| Brain weight (g) | 34.3 ± 1.6 | 34.4 ± 1.9 | 48.3 ± 2.0 | 43.9 ± 1.6 | 55.6 ± 2.7 | 51.3 ± 2.7 |
| Brain:body weight (g/kg) | 18.1 ± 1.3 | 21.8 ± 2.2 | 13.8 ± 0.5 | 17.0 ± 1.1 * | 11.8 ± 0.4 | 16.1 ± 1.8 * |
| Blood gas parameters (average across gestation) | ||||||
| Arterial oxygen saturation (%) | 59 ± 1.3 | 52 ± 1.3 * | 70 ± 0.8 | 58 ± 0.8 * | 62 ± 1.5 | 43 ± 2.0 * |
| Cerebellum | ||||||
| Cross-sectional area (mm2) | 1.3 × 105 ± 1.2 × 104 | 1.3 × 105 ± 1.1 × 104 | 1.6 × 105 ± 1.6 × 104 | 1.8 × 105 ± 1.6 × 104 | 2.1 × 105 ± 1.9 × 104 | 2.2 × 105 ± 1.3 × 104 |
| Cross-sectional area:body weight (mm2/kg) | 7.4 × 104 ± 1.0 × 104 | 8.1 × 104 ± 6.0 × 103 | 4.7 × 104 ± 4.7 × 103 | 7.1 × 104 ± 1.0 × 104 | 4.7 × 104 ± 4.7 × 103 | 6.2 × 104 ± 4.3 × 103 * |
| EGL width (Mm) | 22.0 ± 1.6 | 29.6 ± 2.6 * | 21.7 ± 2.3 | 21.5 ± 3.3 | 14.1 ± 0.7 | 14.0 ± 0.9 |
| ML width (mm) | 142 ± 6 | 112 ± 5 * | 160 ± 12 | 150 ± 11 | 173 ± 8 | 195 ± 5 * |
| WM:cross-sectional area (mm2) | 0.1 ± 0.01 | 0.1 ± 0.02 | 0.1 ± 0.01 | 0.1 ± 0.02 | 0.2 ± 0.02 | 0.2 ± 0.01 |
| The number of Purkinje cells (mm) | 0.016 ± 0.002 | 0.016 ± 0.001 | 0.015 ± 0.001 | 0.013 ± 0.001 | 0.015 ± 0.001 | 0.016 ± 0.001 |
Mean ± SEM are presented for each group.
*
p ≤ 0.05 vs. control.
d GA, days gestational age; FGR, fetal growth restriction; EGL, external granular layer; ML, molecular layer; WM, white matter.