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. 2019 May 22;10:584. doi: 10.3389/fphar.2019.00584

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Copyright © 2019 Ouyang, Huang, Liu, Wu, Liu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RbCl suppresses Ti particle-induced osteolysis in vivo. (A) μCT tomography of calvaria in Ti particle-induced osteolysis mice model. (B) Quantitative analyses from μCT scanning revealing BV/TV, number/percentage of porosity. (C) HE, TRAP of calvaria in Ti particle-induced osteolysis mice (magnification: 200×). (D) Quantitative analysis of TRAP-positive osteoclasts in calvaria in Ti particle-induced osteolysis mice. *p < 0.05. Each experiment was repeated biologically in triplicate independently.