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. 2019 May 29;8(6):giz057. doi: 10.1093/gigascience/giz057

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© The Author(s) 2019. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hypothesized key responses of COX inhibitors in the toxicogenomic fingerprint of diclofenac. Putative causal connections between responses are indicated by dashed arrows; solid arrows indicate transformation reactions, and array color represents estimated t_max for diclofenac. AA: arachidonic acid; BTF: biotransformation (phase I/II); EETs: epoxyeicosatrienoic acids; NSAID: non-steroidal antiinflammatory drug; ROS detox: detoxification of reactive oxygen species. Note: the plot shows a simplified/idealized version of the toxicogenomic fingerprint, the indentified responses, and their connections.