Table 2.

Region of interest

Authors/year	Country	Sample	Age first scan	Num. of follow-up time-points	Follow-up interval (years)	Covariates	Whole-brain/targets
Kasai et al., 2003 [20]	USA	13 FEP	27.2	1	1.5	Age; Inter scan interval	STG; Amygdala hippocampal complex
		14 HC	25.6
Kasai et al., 2003 [21]	USA	13 FEP	27.3	1	1.5	Age; Inter scan interval	HG; PT
		22 HC	25
DeLisi and Hoff 2005 [19]	USA	27 FEP	No reported	2	5–10	Age; Gender; Total brain volume	Temporal lobe
		10 HC
Salisbury et al., 2007 [27]	USA	20 FEP	24.5	1	1.5	No reported	Temporal lobe
		32 HC	24.1
Nakamura et al., 2007 [7]	USA	17 FEP	24.7	1	1.5*	No reported	Frontal, temporal and parieto-occipital lobes
		26 HC	23.6
Koo et al., 2008 [22]	USA	17 FEP	24.6	1	1.5	Inter-scan interval; ICC	CG
		18 HC	23.4
Takahashi et al., 2009 [24]	Australia	23 FEP	21.6		2	Age; Gender; ICV	Insular cortex (Volume)
		26 HC	25.6	1	2.2
Takahashi et al., 2009 [25]	Australia	23 FEP	21.6	1	1.8*	Age; Inter-scan interval	STG [(PP); (HG); (PT); rostral STG; caudal STG]
		22 HC	22.0
Takahashi et al., 2010 [8]	Japan	18 FEP	23.1	1	2.7*	Age; Inter-scan interval; IVC; treatment	STG [subregions (PP), (HG), (PT), rostral STG, and caudal STG]
		20 HC	23.2
Takahashi et al., 2011 [26]	Japan	18 FEP	23.1	1	2.7*	Age, Inter-scan interval; IVC; treatment	Fusiform gyrus; middle and inferior temporal gyrus
		20 HC	23.2
Lee et al., 2015 [23]	USA	22 FEP	25.3	1	1.5	No reported	Insular Gyrus; Temporal Pole
		23 HC	24.2

^*on average.

FEP: first episode of psychosis, HC: healthy control, ICV and IVC: intracraneal volume, STG: superior temporal gyrus, HG: heschl gyrus, PT: planum temporal, CG: cingulate gyrus, PP: planum polare