Table 2.
Resveratrol reduces oxidative stress in endothelial cells.
| Cell Type | Effective Concentration | Effects | Reference |
|---|---|---|---|
| HUVEC | 1–100 µM | NADPH oxidase activity↓ | [72] |
| HUVEC | 10–100 µM | SOD1↑; GPx1↑; Nox4↓ | [73] |
| EA.hy 926 | 100 µM | SOD1↑; SOD2↑; SOD3↑; GPx1↑ catalase↑ | [71] |
| RAS | 1–100 µM | GPx1↑ catalase↑ | [74] |
| HCAEC | 1–10 µM | SOD2↑; SIRT1↑; GSH↑; mtROS↓ | [75] |
| HCAEC | 0.1–100 µM | Nrf2↑; NQO1↑; GCLC↑; HO-1↑ | [16] |
GCLC, γ-glutamylcysteine synthetase; GPx1, glutathione peroxidase 1; HCAEC, human coronary arterial endothelial cells; HO-1, heme oxygenase-1; HUVEC, human umbilical vein endothelial cells; NQO1, NAD(P)H:quinone–oxidoreductase 1; RAS, rat aortic segments; mtROS, mitochondrial reactive oxygen species.