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. 2019 Apr 30;20(9):2155. doi: 10.3390/ijms20092155

Table 3.

Resveratrol reduces endothelin-1 synthesis.

Cell Type Effective Concentration Effects Reference
HUVEC 1–100 µM ROS↓; p-Erk1/2↓; strain-induced ET-1↓ [72]
HUVEC 0.1 µM ET-1↓; eNOS↑; VEGF↑ [79]
HUVEC 30 µM ET-1↓; ECE-1↓ [80]
HASMC 100 µM H2O2-induced ET-1↓; [81]
RASMC 10–100 µM AngII-induced ET-1↓; proliferation↓ [82]

AngII, angiotensin II; ECE-1, endothelin-converting enzyme-1; HASMC, human aortic smooth muscle cells; HUVEC, human umbilical vein endothelial cells; RASMC, rat aortic smooth muscle cells; ROS, reactive oxygen species.