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. 2019 May 10;13:484–492. doi: 10.1016/j.omtm.2019.04.009

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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C5 siRNA Treatment Specifically Lowers Complement Activity and Reduces Symptoms in EAMG Rats as Compared to Control siRNA

In a second EAMG experiment, 24 rats were immunized with Torpedo AChR. After development of weakness, rats were randomized to three groups (n = 8 per group): 5 mg/kg siRNA-C5, 5 mg/kg control siRNA, and saline control. (A) Serum hemolytic activity (sensitized sheep RBC lysis method). Average hemolytic activity is plotted. The error bars are SD. (B) Disease severity of each group. The error bars are SEM. Statistical significance was obtained by t test, comparing saline and control siRNA to siRNA-C5 (*p < 0.05 and ^#p < 0.02).