Scheme 1.
β2,2-homo-bis-ornithine derivatives 1 and 2 syntheses. (a) CH2=CHCN, LiClO4, NEt3 (93%); (b) H2, PtO2, Boc2O, MeOH (21%); (c) H2, Ni Raney, MeOH (1, 98%); (d) 1/H2, Ni Raney, NaOH (2 M), THF/EtOH 2/FmocOSu, K2CO3, H2O, dioxane (2, 72%).
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