aa	amino acid
ADAM17	A Disintegrin and Metalloproteinase 17
CD	cytoplasmic domain
COSMIC	Catalogue of Somatic Mutations in Cancer
dKO	double knock-out
ds	downstream
EGF-R	epidermal growth factor receptor
ELISA	Enzyme-Linked Immunosorbent Assay
ER	endoplasmic reticulum
FGF-2	fibroblast growth factor-2
FSC	forward scatter
HEK	human embryonic kidney cells
ICGC	International Cancer Genome Consortium
IL-6R	interleukin-6 receptor
IntOGen	Integrative Onco Genomics
kDa	kilo Dalton
MPD	membrane-proximal domain
PD	pro-domain
PDI	protein disulfide isomerase
PMA	phorbol 12-myristate 13-acetate
sTNFα	soluble tumor necrosis factor alpha
TCGA	The Cancer Genome Atlas Program
us	upstream
VEGF	vascular endothelial growth factor
wt	wildtype