Table 2.

Differential clinical diagnosis for serotonin syndrome.

Disease	Medication Exposure	Shared Clinical Features	Distinguishing Clinical Features
Serotonin Syndrome	Serotonergic medications	Hypertension	Clonus, hyperreflexia Hyperactive bowel sounds
Neuroleptic Malignant Syndrome	Dopamine antagonists	Tachycardia	No clonus or hyperreflexia Bradykinesia
Anticholinergic Toxicity	Acetylcholine antagonist	Hyperthermia	No clonus or hyperreflexia Dry skin Absent bowel sounds
Malignant Hyperthermia	Halogenated anesthetics Succinylcholine	Altered mental Status	No clonus or hyperreflexia Extreme muscular rigidity

Table adapted from [10,20].