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Fucoidan downregulates the protein expression levels of hypoxia-inducible factor-1α target genes. Western blotting suggested that fucoidan treatment inhibited the expression levels of TWIST, Snail, CAIX and GLUT-1. Data are presented as the means ± standard deviation. *P<0.05 vs. control; #P<0.05 vs. 6.25 µg/ml fucoidan. CAIX, carbonic anhydrase IX; GLUT-1, glucose transporter protein type-1.
