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. 2019 Apr 28;24(9):1671. doi: 10.3390/molecules24091671

Table 1.

Optimization of the reaction conditions.

graphic file with name molecules-24-01671-i001.jpg

Entry [M] Base 2 (equiv) Time (h) Yield of 3a (%) 1
1 FeCl2 CsF 1.5 24 29
2 CoCl2 CsF 1.5 24 21
3 NiCl2 CsF 1.5 24 90
4 NiBr2 CsF 1.5 24 68
5 Ni(cod)2 CsF 1.5 24 16
6 PdCl2 CsF 1.5 24 4
7 NiCl2 Cs2CO3 1.5 24 48
8 NiCl2 KF 1.5 24 0
9 NiCl2 CsF 1.2 24 94 (90)
10 NiCl2 CsF 1.0 24 58
11 NiCl2 CsF 1.2 18 91
12 NiCl2 CsF 1.2 12 87
13 NiCl2 CsF 1.2 6 76

1 Determined by GC analysis of the crude mixture using n-dodecane as an internal standard. An isolated yield is given in parentheses.