Table 1.

Overview of physical device specifications and experimental designs

Parameter	Kidney microphysiological system		Two‐dimensional system
Volume	115 μL		200 μL
Matrix volume	23 μL		N/A
Lumen volume	70 nL		N/A
Flow rate	0.5 μL/min		N/A
Cell type	hRPTECs from donor “HIM‐31”
Estimated cell #	5,000		10,000
Sampling schedule	0, 6, 24 hours + every 48 hours	Every 48 hours	Every 48 hours
Drug exposure time	2 days	10 days	10 days

hRPTECs, human renal proximal tubule cells; min, minute; N/A, not applicable.