Immunohistochemical localization of neurofilament protein (NFP) and S100 protein (S100P) in the axon and the inner core cells, respectively, of human digital Pacinian corpuscles of subjects with ages of 23 (A–D), 55 (E–H)., and 88 (I–L) years. The axon supplying the corpuscles was identifiable in all corpuscles of 23‐ and 55‐year‐old subjects and was not identified in the 88‐year‐old subject. The inner core cells displayed S100P immunoreactivity in all lamellae in the 23‐ and 55‐year‐old subjects, whereas in the older subjects, S100P immunoreactivity was restricted to the outer core lamellae. Scale bar: 50 μm.