Figure 6.

Double immunofluorescence for S100 protein (green fluorescence) and neurofilament protein (red fluorescence; arrows in B and E) in human digital Pacinian corpuscles of subjects with age of 23 (A–C) and 88 (D–F) years. Sections were counterstained with DAPI to ascertain structural details. The axon and the inner core of the 88‐year‐old subject are disarranged, although the corpuscle retained the general organization. Objective 63 × /1.40 oil; pinhole 1.37; XY resolution 139.4 nm and Z resolution 235.8 nm. Scale bar: 50 μm.