Figure 7.

Immunohistochemical characterization of CK20 in human digital cells, identified based on their localization as Merkel's cells, in subjects of different ages: 23 (A), 30 (B), 55 (C), 72 (D), 88 (E) and 90 (F) years. Scale bar: 50 μm. The density of Merkel's cells in the three pre‐established age ranges is shown in the graph. A significant reduction in the density of Merkel's cells was observed with ageing determined as number of Merkel's cells/mm² (upper) and the number of Merkel's cells/rete peg. *P < 0.05, **P < 0.01.