Figure 10.

Sections of glabrous digital skin from 2 subjects with age of 30 (A) and 88 (D) years immunostained to detect Piezo2. The axon of most Meissner's corpuscles displayed Piezo2 immunoreactivity in young individuals (arrows in A, B), whereas this immunoreactivity was restricted to segments of the corpuscle, or even absent in the older subjects (E). The density of Piezo2‐positive Merkel cells in young subjects (C) was higher than that in the old subjects (f, arrow). e, epidermis. Scale bar: 100 μm (A,D), 20 μm (B–C,E–F).