Figure 11.

Several external stimuli acting on the cardiomyocyte. (a) Time curve of external stimuli where $u_1$ inhibits PKC, $u_2$ inhibits RKIP and RKIP dim, $u_3$ inhibits ERK1/2 dim 3P, $u_4$ G${}_{\mathrm{s}}$-coupled ${\mathsf{\beta }}_1$ receptor, $u_5$ inhibits Ras (GTP bound), $u_6$ activates angiotensin II and $u_7$ activates isoproterenol. On the abscissa, we have the time (t) and on the ordinate the activity level (A). (b) Time curve of the nodes of interests where $x_8$ is the activity level of p90RSK, $x_9$ is the activity level of p70S6K, $x_{23}$ is the activity level of Elk1, $x_{24}$ is the activity level of MSK1 and $x_{25}$ is the activity level of c-Myc. On the abscissa, we have the time (t) and on the ordinate the activity level (A).