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. 2019 May 10;20(9):2325. doi: 10.3390/ijms20092325

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Arazyme reduced lipogenesis-related gene and protein expression in the liver. MLX interacting protein like (Mlxipl), sterol regulatory element-binding transcription protein 1 (Srebf1), fatty acid synthase (Fas), acetyl-CoA carboxylase 1 (Acc1), stearoyl-CoA desaturase-1 (Scd1), glycerol-3-phosphate acyltransferase (Gpam), diacylglycerol O-acyltransferase 1 (Dgat1), peroxisome proliferator-activated receptor alpha (Ppara), acyl-coenzyme A oxidase (Acox), carnitine palmitoyltransferase alpha (Cpt1a), and uncoupling protein 2 (Ucp2), glyceraldehyde-3-phosphate dehydrogenase (Gapdh). (A–D) The mRNA expression levels of lipogenesis and lipid oxidation-related genes in the liver were detected by real-time qRT-PCR. (E,F) Hepatic SREBP-1 and FAS protein expression was detected by Western blotting with specific antibodies. Data are presented as means ± SE (n = 4). ^# p < 0.05, ^## p < 0.01 vs. ND; * p < 0.05, ** p < 0.01 vs. HFD by one-way ANOVA.

Arazyme reduced lipogenesis-related gene and protein expression in the liver. MLX interacting protein like (Mlxipl), sterol regulatory element-binding transcription protein 1 (Srebf1), fatty acid synthase (Fas), acetyl-CoA carboxylase 1 (Acc1), stearoyl-CoA desaturase-1 (Scd1), glycerol-3-phosphate acyltransferase (Gpam), diacylglycerol O-acyltransferase 1 (Dgat1), peroxisome proliferator-activated receptor alpha (Ppara), acyl-coenzyme A oxidase (Acox), carnitine palmitoyltransferase alpha (Cpt1a), and uncoupling protein 2 (Ucp2), glyceraldehyde-3-phosphate dehydrogenase (Gapdh). (A–D) The mRNA expression levels of lipogenesis and lipid oxidation-related genes in the liver were detected by real-time qRT-PCR. (E,F) Hepatic SREBP-1 and FAS protein expression was detected by Western blotting with specific antibodies. Data are presented as means ± SE (n = 4). ^# p < 0.05, ^## p < 0.01 vs. ND; * p < 0.05, ** p < 0.01 vs. HFD by one-way ANOVA.