Table III.

Prognostic factors of overall survival for 144 patients with glioblastoma multiforme.

	Univariate	Multivariate
Variable	P-value	P-value	HR	95% CI lower	95% CI upper
Sex	0.353
Age, ≤48 vs. >48	0.88
ATRX mutation	0.519
EGFR mutation	0.241
TERT mutation	0.752
IDH mutation	0.069	0.01	0.204	0.061	0.686
MGMT methylation	0.009	0.12	0.533	0.241	1.178
Survivin high expression	0.041	0.006	2.898	1.355	6.198
KPS	<0.001	0.005	0.343	0.162	0.723
RT vs. RT+TMZ	<0.001	0.005	0.311	0.139	0.697
Resection, GTR vs. STR	0.174	0.151	1.704	0.824	3.522

HR, hazard ratio; CI, confidence interval; EGFR, epidermal growth factor receptor; TERT, telomerase reverse transcriptase; IDH, isocitrate dehydrogenase; MGMT, O⁶-alkylguanine DNA alkyltransferase; KPS, Karnofsky performance status; GTR, gross total resection; STR, subtotal resection; RT, radiotherapy; TMZ, temozolomide.