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. 2019 May 14;18(1):822–829. doi: 10.3892/ol.2019.10356

Figure 4.

Figure 4.

Synergistic effect of AG and DNA damage-inducing reagents. (A) AG1024 enhanced TPL-induced DNA damage. Phosphorylation of H2A.X was detected by western blotting following treatment of cells with TPL and/or AG for 5 days. Values are presented as the mean ± standard error of the mean (n=3). *P<0.05 and **P<0.01 vs. the NT group. (B) AG1024 enhanced cis-induced apoptosis of MDA-MB-231 cells. Cells were treated with Cis and/or AG for 4 days and then cell cycle analysis was used to detect the percentage of cells in the sub-G1 population. (C) Quantified results of the percentage of cells in the sub-G1 population. Data are presented as the mean ± standard error of the mean (n=3). **P<0.01. Cis, cisplatin; AG, AG1024; TPL, triptolide; NT, DMSO treatment.