Table 3.

Changes in the detection of CBPs associated with age and Alzheimer’s disease in different mammal models.

Age
Species	CB	PV	CaM	Method	Area	Reference
Homo sapiens	Decrease	No effect		CC	Cortex, Hippocampus	[200]
	Decrease	No effect	Decrease	tot mRNA	Frontal cortex	[197]
Mus musculus	Decrease	No effect		CC, WB	Striatum	[31]
	Decrease	No effect		CC, WB	Somatosensory cortex	[30]
		Decrease No effect		SI	Hippocampus (CA1) Hippocampus (CA3, DG)	[38]
		Decrease		CC, SI	Brain	[201]
			No effect Increase Decrease	RIA	Striatum Cortex, Cerebellum Diencephalon, Medulla	[196]
Rattus norvegicus	Decrease No effect			WB, ID	Hippocampus Cerebellum	[202]
	Decrease			WB	Striatum	[28]
	Decrease			CC, WB	Auditory system	[203]
	Decrease	No effect		CC, WB	Striatum	[31]
	Decrease	Increase		CC	Somatosensory cortex	[30]
Meriones unguiculatus	Decrease			SI, WB	Hippocampus	[204]
	Decrease	No effect		CC, WB	Striatum	[31]
	Decrease	Increase		CC, WB	Somatosensory cortex	[30]
Mesocricetus auratus	Decrease	No effect		ISH, ARG	Hippocampus, Striatum, Cerebellum	[205]
Alzheimer’s Disease
Species	CB	PV	CaM	Method	Area	Reference
Homo sapiens	Decrease		Decrease	RIA	Frontal, Temporal, Parietal Cortex	[206]
	Decrease			CC, SI	Cortex	[207,208]
	Decrease			CC	Prefrontal cortex	[209]
	Decrease			CC	Temporal cortex	[210]
	Decrease			CC	Hippocampus	[195]
		Decrease		CC	Temporal, Parahippocampal, Parietal cortex, Cerebellum	[211]
		Decrease No effect		CC	Hippocampus	[212]
			Decrease	SI	Cortex	[213]
Mus musculus	Decrease			SI, WB, RT-PCR	Dentate gyrus	[214]
	Decrease			CC, SI	Hippocampus	[215]
		Decrease		SI, WB	Hippocampus	[216]

CC: cell count; WB: Western blot, SI: signal intensity; RIA: radioimmunoassay; ID: immunodot, ISH: in situ hybridization, ARG: autoradiography, CA1: cornu Ammonis 1, CA2: cornu Ammonis 2, DG: dentate gyrus.