Table 1.
Summary of differentially expressed genes (DEGs) obtained after genome-wide transcriptome analysis of ex vivo RV-infected mPCLS.
| Comparison | Total DEGs * | Up Regulated | Down Regulated | |
|---|---|---|---|---|
| BRO effect under baseline condition | ||||
| (Medium/Vehicle) | (Medium/Medium) | 37 | 14 | 23 |
| (Medium/BRO 1:10) | (Medium/Vehicle) | 6693 | 2497 | 4196 |
| RV induced gene regulation | ||||
| (RV/Vehicle) | (RV/Medium) | 1 | 1 | 0 |
| (RV/Vehicle) | (Medium/Vehicle) | 692 | 631 | 61 |
| BRO effect on RV infection | ||||
| (RV/BRO 1:10) | (RV/Vehicle) | 5665 | 2220 | 3445 |
| (RV/BRO 1:100) | (RV/Vehicle) | 1257 | 446 | 811 |
| (RV/BRO 1:1000) | (RV/Vehicle) | 71 | 9 | 62 |
* Differentially-expressed genes (DEGs) were obtained with the criteria fold change <−2 or fold change >2; and ANOVA p-value < 0.05, based on list of genes by using Transcriptome Analysis Console Software (TAC 4.0). Raw data are deposited at GEO database (GSE126832).