Table 2.

BRO modulation of NFkB target genes and related molecules and their biological functions.

Gene	Fold Change		Gene	Fold Change
	RV vs. Med	RV+BRO vs. RV		RV vs. Med	RV+BRO vs. RV
Proinflammatory chemokines/cytokines			Leukocyte activation
Ccl2	5.08 *	−6.20 *	Cd40	7.77 *	1.40
Ccl5	34.23 *	−1.50	Cd69	5.99 *	−1.52
Cxcl10	178.71 *	−6.27 *	Icos/Icosl	1.03/2.43	2.77 */5.90 *
Il1b	1.61	−2.49 *	Apoptosis
Casp1	2.99 *	−2.83 *	Tnfsf10	14.66 *	−61.82 *
Il6	15.56 *	−1.68	Tnfaip3	3.71 *	23.7 *
Il6r	−1.19	4.30 *	Casp8	1.43	−2.14 *
Il6st(gp130)	−1.34	2.98 *	Traf1/2	1.67/1.38	6.4 */6.5 *
Adam17	−1.10	2.43 *	Inducible enzymes and prostaglandin
Tnf	4.05 *	2.60 *	Nos2	3.76 *	−28.68 *
Leukocyte infiltration			Ptgs2	2.88 *	2.94 *
Icam1	2.25 *	7.66 *	Ptges	1.13	−4.40 *
Vcam1	8.36 *	2.16 *	Namp	5.03 *	−3.02 *

* Fold change <−2 or fold change >2; and ANOVA p-value < 0.05.