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Effect of DLLD combined with UTMD on BGC-823 cell apoptosis. Cells were treated with PBS, DOC, DLLD or DLLD plus UTMD for 48 h. (A) Cell apoptosis analysis by Annexin V and propidium iodide staining. (B) Quantified levels of cell apoptosis. Values are presented as the mean ± SD (n=5 for each group). *P<0.05 and ***P<0.001 vs. Control. ###P<0.001 vs. DOC. &&&P<0.001 vs. DLLD. DOC, docetaxel; DLLD, DOC-loaded lipid microbubble; UTMD, ultrasound-triggered microbubble destruction.
