Table 1.
Cytokines/chemokines levels in infected wild-type (WT) and cystic fibrosis (CF) mice treated or not treated with bovine lactoferrin (bLf).
| Cytokine/chemokine (pg/mL) | WT | WT bLf | CF | CF bLf |
|---|---|---|---|---|
| IL-1α | 95 ± 22 | 78±45 | 167 ± 93 | 110 ± 82 |
| IL-1β | 130 ± 32 | 119 ± 40 | 175 ± 65 | 124 ± 66 |
| IL-2 | ND | ND | ND | ND |
| IL-3 | 3 ± 1 | 3 ± 2 | 3 ± 1 | 3 ± 2 |
| IL-4 | ND | ND | ND | ND |
| IL-5 | 3 ± 1 | 6 ± 2 | 5 ± 2 | 5 ± 1 |
| IL-6 | 9 ± 5 | 6 ± 4 | 11 ± 4 | 9 ± 4 |
| IL-9 | ND | ND | ND | ND |
| IL-10 | 12 ± 3 | 10 ± 4 | 17 ± 4 | 12 ± 4 |
| IL-12(p40) | 10 ± 6 | 16 ± 9 | 7 ± 1 | 9 ± 4 |
| IL-12(p70) | 69 ± 14 | 64 ± 18 | 105 ± 35 | 71 ± 43 |
| IL-13 | 77 ± 15 | 83 ± 17 | 92 ± 13 | 78 ± 10 |
| IL-17 | 11 ± 3 | 14 ± 8 | 5 ± 2 | 11 ± 6 |
| Eotaxin | 540 ± 167 | 417 ± 93 | 612 ± 149 | 390 ± 120 |
| G-CSF | 301 ± 216 | 134 ± 162 | 479 ± 252 | 283 ± 225 |
| GM-CSF | ND | ND | ND | ND |
| IFN-γ | 11 ± 1 | 12 ± 5 | 11 ± 2 | 11 ± 5 |
| KC | 90 ± 50 | 67 ± 29 | 131 ± 63 | 79 ± 41 |
| RANTES | 42 ± 44 | 63 ± 26 | 20 ± 21 | 40 ± 14 |
| TNF-α | 35 ± 14 | 33 ± 9 | 52 ± 22 | 38 ± 23 |
Cytokine/chemokine levels in murine lung homogenates after 7 treatments with aerosol administration of 50 µL sterile saline or 200 µg/50 µL bLf. IL: Interleukin; G-CSF: Granulocyte Colony-Stimulating Factor; GM-CSF: granulocyte-macrophage colony–stimulating factor; IFN: Interferon; KC: Keratinocyte Chemoattractant; TNF: Tumor Necrosis Factor. ND: Not Detected.