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. 2019 May 10;20(9):2312. doi: 10.3390/ijms20092312

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Increased AHR signaling and loss of white adipose tissue (WAT) weight levels in 3MC-treated Tiparp^−/− mice. (A) WAT weight was expressed as a percentage of total body weight on day 6. The mRNA expression levels of the AHR target genes Cyp1a1 (B), Tiparp (C), Pnpla2 (D), Hsl (E) and serum β-hydroxybutyrate (F) were measured. Data represent the mean ± SEM; with an n = 3 (A). ^a p < 0.05 two-way ANOVA comparison between genotype-matched corn oil- and 3MC-treated mice followed by a Tukey’s post hoc test for multiple comparisons and ^b p < 0.05 two-way ANOVA comparison between treatment-matched WT and Tiparp^−/− mice followed by a Tukey’s post hoc test.