Table 3.
Analgesic activity using tail-flick test for tested compounds
| Latency (seconds) | Potency (%) | ||||
|---|---|---|---|---|---|
| 0 minutes | 30 minutes | 60 minutes | 120 minutes | ||
| Control | 3.2±0.4 | 4.1±0.4b | 4.1±0.3b | 4.0±0.2b | — |
| Naproxen | 3.5±0.6 | 5.3±0.3a | 6.2±0.4a | 7.0±0.4a | 100 |
| 5 | 3.5±0.2 | 3.9±0.3b | 3.9±0.4b | 3.9±0.2b | 55.7 |
| 6 | 3.4±0.2 | 4.6±0.3 | 4.0±0.2b | 4.2±0.3b | 60.0 |
| 7 | 3.6±0.3 | 3.9±0.4b | 3.6±0.3b | 4.1±0.2b | 58.6 |
| 8 | 3.1±0.1 | 5.0±0.2a | 4.9±0.3a,b | 5.9±0.5a | 84.3 |
| 9 | 3.3±0.3 | 3.7±0.2b | 3.8±0.3b | 4.0±0.3b | 57.1 |
| 10 | 3.4±0.3 | 3.1±0.3b | 4.6±0.4b | 5.7±0.2a,b | 81.4 |
| 11 | 3.4±0.3 | 4.8±0.5a | 4.8±0.4b | 4.8±0.2a,b | 68.6 |
| 12 | 3.4±0.3 | 4.6±0.3 | 4.0±0.4b | 3.8±0.3b | 54.3 |
| 13 | 3.4±0.2 | 3.8±0.2b | 3.4±0.2 | 3.5±0.4b | 50.0 |
| 14 | 3.3±0.3 | 6.1±0.4a | 5.6±0.2a | 5.7±0.3a,b | 81.4 |
| 15 | 3.3±0.3 | 4.2±0.4 | 3.9±0.2b | 4.5±0.3b | 64.3 |
Notes: Values represent means ± SE of six rats for each group. aP<0.05 vs control (LSD followed by Dunnett’s test); bP<0.05 vs parent compound (LSD followed by Dunnett’s test). All compounds were dissolved in DMSO (5 mg/kg orally), and the parent compound was also dissolved in DMSO (2.5 mg/kg orally).