Table 5.
CZ48 and CPT organ distribution parameters from cosolvent, NS-S and NS-L in mice after i.v. administration (n=6)
| Organs | CZ48 | CPT | ||||
|---|---|---|---|---|---|---|
| Cosolvent | NS-S | NS-L | Cosolvent | NS-S | NS-L | |
| AUC/Dose[(ng/g)*h/(mg/kg)] | ||||||
| Heart | 296.14 | 378.34 | 169.67 | 18.75 | 32.93 | 23.16 |
| Liver | 690.54 | 15,324.07 | 23,288.49 | 99.03 | 181.38 | 189.48 |
| Spleen | 282.28 | 5,374.30 | 3,350.07 | 34.34 | 48.51 | 57.90 |
| Lung | 1,038.38 | 13,686.92 | 1,612.12 | 34.18 | 55.18 | 39.55 |
| Kidney | 604.57 | 332.13 | 355.41 | 57.25 | 57.35 | 59.94 |
| Brain | 59.59 | 34.61 | 34.14 | 8.25 | 8.91 | 8.24 |
| Plasma | 156.05 | 178.06 | 146.85 | 2.89 | 6.89 | 3.81 |
| t1/2 (hrs) | ||||||
| Heart | 0.76 | 8.29 | 4.77 | 0.99 | 7.13 | 6.49 |
| Liver | 0.84 | 1.96 | 2.74 | 1.17 | 6.31 | 5.99 |
| Spleen | 0.93 | 1.64 | 1.92 | 0.81 | 2.99 | 4.58 |
| Lung | 2.00 | 38.21 | 3.07 | 0.77 | 7.28 | 3.81 |
| Kidney | 0.81 | 3.20 | 3.17 | 1.48 | 4.16 | 8.24 |
| Brain | 0.62 | 4.45 | 4.16 | 0.68 | 4.02 | 4.04 |
| Plasma | 0.70 | 5.00 | 5.58 | 0.40 | 12.51 | 5.81 |
| Cmax/Dose [(ng/g)*hr/(mg/kg)] | ||||||
| Heart | 263.04 | 148.24 | 70.91 | 11.18 | 11.55 | 10.73 |
| Liver | 543.24 | 5,521.13 | 86,253.18 | 50.99 | 34.22 | 31.03 |
| Spleen | 200.65 | 3,230.42 | 2,014.29 | 21.46 | 16.15 | 14.40 |
| Lung | 309.97 | 1,689.83 | 5,036.33 | 29.26 | 18.71 | 20.95 |
| Kidney | 488.36 | 194.71 | 386.09 | 21.78 | 17.38 | 15.85 |
| Brain | 49.63 | 9.99 | 9.41 | 7.28 | 3.91 | 4.15 |
| Plasma | 154.42 | 49.48 | 69.79 | 3.53 | 2.51 | 1.55 |