Table 1.
Key genetic alterations and copy-number variations in the 15 PDXs used for study
| PDXs | TP53 | KRAS | SMAD4 | PTEN |
|---|---|---|---|---|
| P410 | MUT | WT | WT | WT |
| P374 | MUT | MUT | WT | WT |
| P281 | MUT | MUT | MUT | WT |
| P265 | MUT; Amplification | MUT; Amplification | WT; Deletion | WT |
| P253 | MUT | MUT | WT | WT |
| P215 | MUT | MUT | WT | WT |
| P198 | MUT | MUT | MUT | WT; Deletion |
| P194 | MUT | MUT | Deep deletiona | WT |
| JH015 | MUT | MUT | WT; Deletion | WT |
| JH010 | MUT | MUT | MUT | WT |
| P420 | WT | WT | WT | WT |
| P286 | WT | MUT | WT | WT |
| P219 | WT | MUT | WT | WT |
| JH033 | WT | MUT | WT; Deletion | WT; Deletion |
| JH024 | WT | MUT | MUT; Deletion | WT |
Abbreviations: MUT, mutated; WT, wild type.
a
Deep deletion = deletion in both copies of gene.