Table 6.
Physical stability of SLM-loaded nanomicelles in phosphate buffer saline (PBS) without and with HSA (Mean ± SD, n = 3).
| SLM-PNM | SLM-MNM | |||
|---|---|---|---|---|
| Medium | Average Diameter (nm) | PdI | Average Diameter (nm) | PdI |
| PBS 24 h | 68.0 ± 1.1 | 0.08 ± 0.01 | 69.7 ± 3.4 | 0.07 ± 0.01 |
| PBS 48 h | 64.1 ± 1.8 | 0.12 ± 0.02 | 75.8 ± 4.4 | 0.08 ± 0.03 |
| PBS 72 h | 66.6 ± 1.2 | 0.09 ± 0.01 | 72.0 ± 1.4 | 0.11 ± 0.01 |
| PBS + HSA 24 h | 69.6 ± 1.3 | 0.21 ± 0.02 | 75.6 ± 6.3 | 0.26 ± 0.01 |
| PBS + HSA 48 h | 70.6 ± 0.4 | 0.24 ± 0.01 | 74.0 ± 2.1 | 0.24 ± 0.01 |
| PBS + HSA 72 h | 70.9 ± 0.2 | 0.25 ± 0.01 | 70.2 ± 1.1 | 0.25 ± 0.01 |
SLM-PNM: silymarin-loaded polymeric nanomicelles; SLM-MNM: silymarin-loaded mixed nanomicelles; PBS: phosphate buffer saline; HSA: human serum albumin; PdI: polydispersity index.