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Cytoplasmic expression of ERβ1 in patients with EGFR exon 21 L858R mutation is associated with survival. (A) Progression-free survival and (B) overall survival were significantly increased in patients with EGFR exon 21 L858R mutated non-small cell lung cancer and low cytoplasmic ERβ1 expression compared with high expression. P=0.005; P=0.002, respectively. Symbols represent censored observations. EGFR, epidermal growth factor receptor; ERβ1, estrogen receptor β1; cyto, cytoplasmic.
