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. 2019 May 5;20(9):2211. doi: 10.3390/ijms20092211

Figure 1.

Figure 1

Antiallodynic and antihyperalgesic effects of cobalt protoporphyrin IX (CoPP) in wild-type (WT), neuronal nitric oxide synthase knock-out (NOS1-KO), and inducible nitric oxide synthase knock-out (NOS2-KO) mice with peripheral inflammation. Mechanical allodynia (A,B) and thermal hyperalgesia (C,D) in ipsilateral (continuous lines) and contralateral paws (discontinuous lines) of WT, NOS1-KO, and NOS2-KO mice treated for 11 days with vehicle or CoPP at 4, 7, 10, and 14 days after complete Freund’s adjuvant (CFA) injection are shown. For each genotype, day and treatment were assessed; * denotes significant differences when compared with their respective contralateral paw, + denotes significant differences when compared with their respective ipsilateral paw treated with CoPP, and # denotes significant differences of the same treatment between genotypes (p < 0.05, one-way ANOVA, Student–Newman–Keuls test). Data are shown as mean values ± SEM; n = 8 animals per group.