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. 2019 May 8;24(9):1783. doi: 10.3390/molecules24091783

Table 3.

In vitro inhibition of aromatase activities by the test compounds and reference agents. Relative conversions (Rel. conv., control incubation with no inhibition is 100%) measured in the presence of 10 μM concentration of the compound tested. Mean ± SD, n = 3. IC50: inhibitor concentration decreasing the enzyme activity to 50%. SD: standard deviation.

Compound Structure IC50 ± SD (µM) or
Rel. conv. ± SD (%)
9 graphic file with name molecules-24-01783-i001.jpg IC50 = 0.49 ± 0.07
20 graphic file with name molecules-24-01783-i002.jpg IC50 = 5.0 ± 2.4
17 graphic file with name molecules-24-01783-i003.jpg IC50 > 10 93 ± 11
21 graphic file with name molecules-24-01783-i004.jpg IC50 > 10 100 ± 6
22 graphic file with name molecules-24-01783-i005.jpg IC50 = 2.4 ± 0.4
Androst-4-ene-3,17-dione graphic file with name molecules-24-01783-i006.jpg IC50 = 0.22 ± 0.2
Androst-1,4-diene-3,17-dione graphic file with name molecules-24-01783-i007.jpg IC50 = 0.26 ± 0.06