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Protein kinase inhibitors can selectively inhibit the activity of their targeted altered kinase leading to PD-L1 downregulation and restoration of both apoptosis and MHC-I expression. Combination therapies with PD-1/PD-L1 blocking therapies will result in enhanced T-cell response against tumor cells. RK (receptor kinase), RKI (receptor Kinase Inhibitor), KI (kinase Inhibitor), Pan-KI (pan-kinase inhibitor), TCR (T-cell receptor). PTEN-M: PTEN modulator.
