Table 1.
Study details
| Author | Publication year | Country | Data collection years | Study cohort | Method of follow-up | Women in cohort (n) | PAS women (n) | PAS women (%) | Type of PAS | Duration of follow-up | Subsequent pregnancies | Future health |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lanzino et al. [19] | 1991 | Italy (single centre) | 1978–1988 | prospective cohort of patients aged 16–45 with IS or TIA | clinical visit or telephone interview | 59 | 2 | 3 | IS (pp) | mean 5.8 y, range 6mo-11 y | x | |
| Lamy et al. [20] | 2000 | France (9 centres) | 1987–1997 | retrospective cohort of women aged 15–40 admitted for first IS or CVT | written questionnaire, phone interview, patient records verification of substequent strokes | 411 | 37 | 9 | 28 IS/9 CVT | mean 5, SD 2.4, range 0.8–11.3 y | x | |
| Mehraein et al. [21] | 2003 | Germany (single centre) | 1976–1996 | retrospective cohort of patients treated for CVT | telephone interview, mailed questionnaire | 39 | 4* | 10 | CVT (2 pp., 1 w9, 1 w40) | mean 10.25, range 1–20 y | x | |
| Breteau et al. [22] | 2003 | France (2 centres) | 1995–1998 | retrospective cohort of patient with CVT from two hospitals follow up by visit/phone | visit or telephone interview | 42 | 3 | 7 | CVT (pp) | median 36, range 12–60 mo | x | |
| Coppage et al. [21] | 2004 | USA (3 centres) | 1990–2002 | reprospective cohort of pregnant women with a history stroke | hospital charts | 23 | 4 | 17 | 1 CVT (pp); 1 NS (w6); 1 NS (w39); 1 IS (pp) | nr | x | |
| Ferro et al. [23] | 2004 | multinational, multicentre | 1998–2001 | prospective international multicentre study of CVT patients | clinical visits, telephone interview | 465 | 77 | 17 | CVT (24 p, 53 pp) | mean 18.6, SD 11.1, median 16 mo | x | |
| Appenzeller et al. [24] | 2005 | Brazil (single centre) | 1992–2002 | retrospective cohort patients (subgroup of women) with CVT | follow up by neurology/hematolyogy department | 18 | 6 | 33 | CVT (pp) | mean 46, range 11–145 mo | x | x |
| Ertresvg et al. [30] | 2007 | Norway (single centre) | 1997–1999 | prospective case-control study of women referred to neurology due to transient neurological symptoms | mailed questionnaires | 41 | 2 | 5 | IS (p) | 5 y | x | |
| Crovetto et al. [25] | 2012 | Italy (single centre) | 2000–2009 | retrospective cohort of w12 beyond pregnant women with a history of IS | contact at least at 6 mo, phone contact in case of no show | 24 | 1 | 4 | IS (p) | nr | x | |
| Gastrich et al. [26] | 2012 | New Jersey (non federal hospitals) | 1994–2009 | retrospective case-control register study of pre-eclamptic women with or without MI/stroke | register/hospital charts | 353 | 90 | 25 | SAH/ICH/IS/CVT*** | up to 16 years | x | |
| Ciron et al. [27] | 2013 | France (4 centres) | 1995–2012 | retrospective cohort of women with CVT at age 15–40 | telephone interview, clinical visit offered | 62 | 6 | 10 | CVT (4 p, 2 pp) | mean 89.5+/−60.6 mo, median 76 mo, ~ 6 y | x | |
| Alebeek et al. [28] | 2018 | Netherlands (single centre) | 1980–2010 | prospective cohort of patients aged 18–50 with IS or TIA | telephone interview, mailed questionnaire | 213 | 20** | 9 | IS | mean 14.8, SD 10.0 y | x | x |
PAS Pregnancy-associated stroke, p pregnancy, pp postpartum, w pregnancy week, IS ischemic stroke, ICH intracerebral hemorrhage, SAH subarachnoid hemorrhage, CVT cerebral venous thrombosis, y year, mo month, nr not reported. *It is possible that there were more womenwith PAS in the cohort, but it was stated that 4 PAS women had subsequent pregnancies. ** Study included patients with ischemic stroke (n = 9) or TIA (n = 11) as PAS types, but did not specify outcomes between these subtypes. *** Numbers not specified