Table 2.
Subsequent pregnancies and their outcomes in women with a history of PAS
| Author | PAS women (n) | CVT (n) | IS (n) | NS (n) | Women with subsequent pregnancies (n) | Pregnancies (n) | Miscarriage (n) | Induced abortion (n) | Live births (n) | Fetal death (n) | Pregnancy > w22 complications raported (n) | Uncomplicated pregnancies (n) | PROM (n) | Pre-eclampsia (n) | Stroke recurrence(n) | Underlying disease |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Appenzeller et al. [24] | 6 | 6 | 0 | 0 | 2 | 2 | nr | nr | 2 | 0 | 2 | 2 | 0 | 0 | 0 | none |
| Lamy et al. [20] | 37 | 9 | 28 | 0 | 15 | 24 | nr | nr | 11 | 0 | nr | nr | nr | nr | nr | 2 CVT patients: hematologic disease |
| Crovetto et al. [25] | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | Antiphospholipid syndrome |
| Coppage et al. [21] | 4 | 1 | 1 | 2 | 4 | 9 | 3 | 0 | 5 | 1 | 6 | 1 | 3 | 1 | 0 | 1 patient PSD; 1 patient PCD; 2 patients uncontrolled hyprtension |
| Ciron et al.* [27] | 6 | 6 | 0 | 0 | nr | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 patient: sickle cell disease |
| Mehraein et al. [29] | 4 | 4 | 0 | 0 | 4 | 6 | 1 | 0 | 5 | 0 | 5 | 5 | 0 | 0 | 0 | nr |
| Ferro et al. ** [23] | 77 | 77 | 0 | 0 | nr | 11 | 1 | 2 | 8 | 0 | 8 | 8 | 0 | 0 | 0 | nr |
| Total | 135 | 103 | 30 | 2 | 26 | 55 | 6 | 3 | 32 | 1 | 22 | 17 | 3 | 1 | 1 |
CVT Cerebral vein thrombosis, IS Ischemic stroke, NS stroke type not specified, PROM premature rupture of membranes, PSD Protein S deficiency, PCD Protein C deficiency, nr not reported for women with PAS. *Ciron et al. reported that in 9.7% (n = 6) of 62 women with CVT in reproductive age it was related to pregnancy. The authors report the number of pregnancies and their outcomes for one women with a PAS history, but do not state whether the other women with PAS history had pregnancies. **Ferro et al. reported that there were 8 uncomplicated pregnancies, 1 miscarriage and 2 induced abortions, but do not state amongst how many women these pregnancies occurred