Fig. 3.

Relative change in ${\text{WT}}_{\frac{1}{2}}$ for Imatinib-Nilotinib rotation protocols. Each smaller heatmap shows the effects of different rotation timings at a certain dose of each drug. For instance, the (600 Imatinib, 1200 Nilotinib) box in the (50%, 50%) heatmap shows the effect of a drug rotation with t_a=600 timesteps of Imatinib treatment (ca. 1 month) followed by t_b=1200 timesteps of Nilotinib treatment (ca. 2 months), see Fig. 1, with both drug concentrations set such that cell growth was slowed by 50%. In half the simulations the rotation started with Imatinib, and in the other half it started with Nilotinib. The colours correspond to the change in ${\text{WT}}_{\frac{1}{2}}$ compared to a constant Imatinib or Nilotinib, whichever is better, with the same degree of inhibition. A zero duration uptime of one drug implies a constant concentration of the other. Zero-zero uptime boxes are set as 0%, as they cannot be assessed since drug resistance almost never occurs without selective pressure from drugs