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. 2019 May 28;19:508. doi: 10.1186/s12885-019-5690-5

Table 1.

Global parameters

Parameter Symbol Value
Population size avg. N^ 250 000 cells [24]
Population size spring constant κ 1.0
Mutation rate multiplier μ 10−7 mutations/divisiona
Unmodified growth rate s (0) 0.016 divisions/timestepb [30]

aThe number of mutations in a single residue per new cell where only one transversion can result in the specific amino-acid change. Mutations that result from transitions or more than one possible SNV have higher mutation rates, see Additional file 1: Section 5 and Table S1

bCorresponds to approximately 0.3 – 0.4 divisions per day