Summary of results: Pain‐free and headache relief
	Baseline pain	Studies	Attacks treated	Treatment (%)	Placebo or comparator (%)	Relative benefit (95% CI)	NNT (95% CI)
Pain‐free at 2 h
Naproxen 500/825 mg vs placebo	≥ mod	4	2149	17	8	2.0 (1.6 to 2.6)	11 (8.7 to 17)
Naproxen 500 mg vs placebo	≥ mod	3	1951	16	9	1.9 (1.5 to 2.4)	13 (9.7 to 22)
Naproxen 500 mg vs sumatriptan 50 mg	≥ mod	1	474	18	20	Not calculated	Not calculated
Headache relief at 2 h
Naproxen 500/825 mg vs placebo	≥ mod	4	2149	45	29	1.6 (1.4 to 1.8)	6.0 (4.8 to 7.9)
Naproxen 500 mg vs placebo	≥ mod	3	1951	44	28	1.6 (1.4 to 1.8)	6.2 (4.9 to 8.3)
Naproxen 500 mg vs sumatriptan 50 mg	≥ mod	1	474	46	49	Not calculated	Not calculated
Sustained pain‐free during the 24 h post dose
Naproxen 500/825 mg vs placebo	≥ mod	4	2149	12	7	1.8 (1.4 to 2.4)	19 (13 to 34)
Naproxen 500 mg vs placebo	≥ mod	3	1951	11	7	1.6 (1.2 to 2.1)	26 (16 to 70)
Naproxen 500 mg vs sumatriptan 50 mg	≥ mod	1	474	12	11	Not calculated	Not calculated
Sustained headache relief during the 24 h post dose
Naproxen 500/825 mg vs placebo	≥ mod	4	2149	30	18	1.7 (1.5 to 2.0)	8.3 (6.4 to 12)
Naproxen 500 mg vs placebo	≥ mod	3	1951	28	17	1.7 (1.4 to 2.0)	9.3 (6.9 to 14)
Naproxen 500 mg vs sumatriptan 50 mg	≥ mod	1	474	25	29	Not calculated	Not calculated