Study ID	Treatment	Any AE	SAE	AE withdrawal	Other withdrawal
Brandes 2007 Study 1	(1) naprox 500 mg, n = 361 (2) placebo, n = 365	≤ 24 h: (1) 48/361 (2) 45/365	No SAE reported	None reported	Exclusions ‐ took medication but no evaluable data: (1) 5 (2) 5
Brandes 2007 Study 2	(1) naprox 500 mg, n = 371 (2) placebo, n = 387	≤ 24 h: (1) 52/371 (2) 39/387	No SAE reported	None reported	Exclusions ‐ took medication but no evaluable data: (1) 7 (2) 5
Smith 2005	(1) naprox 500 mg, n = 250 (2) placebo, n = 241	AE reported for safety population at 72 h (1) 55/250 (2) 36/242	None	None	None reported
Wentz 2008	(1) naprox 825 mg, n = 96 (2) placebo, n = 102	AE reported until 'study discharge' (1) 22/96 (2) 8/102	None	None	16 excluded (10 had no qualifying headache, 3 lost to follow‐up, 1 protocol violation, 2 'other')
AE: adverse event; naprox: naproxen; SAE: serious adverse event.