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. 2019 May 28;21:129. doi: 10.1186/s13075-019-1919-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The flow chart of patient recruitment. All Japanese patients with systemic sclerosis (SSc) hospitalized to our clinic for initial evaluation were collected. Patients who did not meet the classification criteria for SSc established by American College of Rheumatology and European League Against Rheumatism in 2013 (ACR/EULAR criteria 2013) were excluded. In total, 198 patients were recruited into our study