Table 5.
Isolated heart functional study
| AL (n = 8) | AL/IF (n = 9) | IF (n = 13) | |
|---|---|---|---|
| BW (g) | 458 ± 35 | 404 ± 39* | 389 ± 32* |
| LVW (g) | 1.05 ± 0.12 | 1.06 ± 0.21 | 0.99 ± 0.13 |
| LVW/BW (g/kg) | 2.29 ± 0.13 | 2.62 ± 0.40 | 2.54 ± 0.32 |
| LVW/V0 (g/mL) | 2.56 (2.18–2.90) | 2.90 (2.54–3.92) | 3.35 (3.11–3.75)* |
| DP0 (mmHg) | 44.7 ± 16.9 | 30.8 ± 11.6 | 41.4 ± 16.7 |
| DP25 (mmHg) | 53.6 ± 22.3 | 50.0 ± 17.8 | 53.0 ± 26.5 |
| DPmax | 58.3 ± 22.0 | 51.4 ± 18.0 | 56.3 ± 25.0 |
| +dP/dt (mmHg/s) | 1562 ± 590 | 1034 ± 385 | 1495 ± 643 |
| Systolic stress25 (g/cm2) | 80.8 ± 30.0 | 70.0 ± 31.0 | 65.0 ± 33.4 |
| -dP/dt (mmHg/s) | 1000 ± 340 | 562 ± 283 | 831 ± 341 |
| Δ V25 (%) | 49.0 ± 6.20 | 61.0 ± 21.5 | 57.0 ± 17.3 |
| Strain 20 g/cm2 (%) | 5.89 ± 0.92 | 7.50 ± 2.19 | 7.00 ± 1.88 |
Data as mean ± standard deviation or median and 25th and 75th percentiles. AL ad libitum fed, AL/IF ad libitum before myocardial infarction (MI) and intermittently fasted after MI, IF intermittently fasted before and after MI. BW body weight, LVW left ventricular (LV) weight, DP0 LV developed pressure at zero diastolic pressure, DP25 LV developed pressure at diastolic pressure of 25 mmHg, DPmax maximum developed pressure, +dP/dt maximum rate of pressure development; Systolic stress25 LV systolic stress at diastolic pressure of 25 mmHg, −dP/dt maximum rate of ventricular pressure decline, Δ V25 percentage of variation in LV volume required to increase diastolic pressure from 0 to 25 mmHg, Strain 20 g/cm2 percentage of myocardial strain caused by a diastolic stress of 20 g/cm2. ANOVA and Tukey or Kruskal-Wallis and Dunn; * p < 0.05 vs AL; # p < 0.05 vs AL/IF