Fig. 8.

TNFα gene expression at 4 h post-stroke is suppressed by clenbuterol administration after stroke onset. a Experimental design. C57BL/6 mice were given 1 mg/kg clenbuterol i.p. 3 h after photothrombotic cortical stroke and peri-infarct cortex was collected 1 h later (at 4 h after stroke) for gene expression analysis. b Expression of pro-inflammatory genes TNFα and iNOS were normalized to expression in saline-treated sham mice. c Expression of the anti-inflammatory genes IL-10 and Ym1. Two-way ANOVA with Tukey’s multiple comparisons test (n = 4–8 mice per group). Bars, mean ± SEM; *p < 0.05, **p < 0.01